4th Edition: A Tally

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Classes: 64
Races: 40
Powers:7,791
Feats: 3,066
Items: 9,014
Paragon Paths: 547
Epic Destinies: 107

This information is taken from a list that a recent episode of Critical Hits spoke of. The list includes setting specific stuff like Thri-Kreen, the Spellplague powers, and so on.